Finding Atrial Fibrillation in Stroke - Evaluation of Enhanced and Prolonged Holter Monitoring

Institut fÃ¼r anwendungsorientierte Forschung und klinische Studien

Status

Completed

Conditions

Stroke

Treatments

Other: standard care

Other: prolonged ECG monitoring

Study type

Interventional

Funder types

Other

Identifiers

NCT01855035

Find-AF randomised

Details and patient eligibility

About

The purpose of this study is to assess whether repeated enhanced and prolonged ECG monitoring after ischemic stroke results in a higher detection of atrial fibrillation (/flutter) compared to usual care (at least 24 hour of cardiac monitoring).

Enrollment

402 patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Recent cerebral ischemia defined as stroke (sudden focal neurologic deficit lasting > 24h consistent with the territory of a major cerebral artery and categorised as ischemic) and/or a corresponding lesion on brain imaging.
Stroke symptoms started ≤ 7 days ago.
Age ≥ 60 years.
Modified Rankin scale ≤ 2 (prior to index event).

Exclusion criteria

Known history of atrial fibrillation/flutter or atrial fibrillation/flutter on admission ECG.
Indication for oral anticoagulation at randomisation.
Absolute contra-indication against oral anticoagulation at randomisation.
Intracerebral bleeding in medical history.
Patient scheduled for Holter-ECG or cardiac Event-Recording monitoring ≥ 48 hours.
Significant carotid artery or vertebral artery stenosis > 50% (NASCET classification), significant intracranial artery stenosis suspicious of atherosclerotic origin or acute arterial dissection explanatory of stroke symptoms.
Implanted pacemaker device or cardioverter/defibrillator.
Life expectancy < 1 year for reasons other than stroke (e.g. metastatic cancer).
Concomitant participation in other controlled randomised trial.