Finding the Latent Treponema Pallidum

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Syphilis

Treatments: Diagnostic Test: RPR Titer

Study type: Observational

Funder types: Other

Identifiers

NCT03754517

The reaseon of serofast

Details and patient eligibility

About

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, srum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.

Full description

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, serum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All clinical diagnosis of syphilis cases

Exclusion criteria

• Auto-immune disease (such as SLE)
• Lyme disease

Trial design

30 participants in 3 patient groups

Serofast status

Description:

The syphilitic patients who remain in a serologically positive state after therapy

Treatment:

Diagnostic Test: RPR Titer

Untreated

Description:

untreated syphilis cases

Treatment:

Diagnostic Test: RPR Titer

Serological cure

Description:

In the early syphilis patients, at 6 months following treatment, a serological cure was defined as either a negative RPR or ≥2 dilution (4-fold) decrease in the RPR titer. In the late syphilis patients, at 12 months following treatment, a serological cure was defined as either a negative RPR or ≥2 dilution (4-fold) decrease in the RPR titer.

Treatment:

Diagnostic Test: RPR Titer