FiO2 and Outcomes After Cardiac Surgery With Cardiopulmonary Bypass

Seoul National University

Status: Withdrawn

Conditions: Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass

Treatments: Other: Fraction of inspired oxygen level

Study type: Interventional

Funder types: Other

Identifiers

NCT03939832

FiO2 CPB

Details and patient eligibility

About

Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery using CPB has not been reached among practitioners yet.

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients scheduled for cardiac surgery using cardiopulmonary bypass

Exclusion criteria

• Planned implementation of deep hypothermic circulatory arrest
• Preoperative respiratory support with the fraction of inspired oxygen of 0.5 and more.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups

FiO2 0.5

Active Comparator group

Treatment:

Other: Fraction of inspired oxygen level

FiO2 1.0

Active Comparator group

Treatment:

Other: Fraction of inspired oxygen level