FIO2 Influences SvO2 Interpretation and Fick-based Cardiac Output Assessment

Chang Gung Medical Foundation

Status: Completed

Conditions: Cardiac Output

Treatments: Other: fraction of inspired oxygen (FIO2)

Study type: Interventional

Funder types: Other

Identifiers

NCT04265924

104-7177B

Details and patient eligibility

About

In this study, the investigators sought to clarify the influence of FIO2 levels on the variables in the Fick equation and then assessed the influence of each variable on the accuracy of Fick-CO measurements in patients undergoing cardiac surgery.

Full description

Patients who are aged ≥20 years, are undergoing planned elective cardiac surgery, and provided signed informed consent are included in the present study. Any patients with an intra-cardiac shunt are excluded.

The patients are randomly assigned to 2 groups: FIO2 <0.7 or FIO2 >0.85. And during the surgery, the oximeter values are kept ≥98%. Intra-operatively, FIO2, PaO2, SaO2, SvO2, PvO2, Hb, blood pH values, body temperature and TD-CO are recorded.

Enrollment: 50 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing planned elective cardiac surgery
• agree to sign informed consent

Exclusion criteria

• intra-cardiac shunt

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

>0.85 FIO2 group

Active Comparator group

Description:

This group receives FIO2 \>0.85 during the surgery.

Treatment:

Other: fraction of inspired oxygen (FIO2)

<0.7 FIO2 group

Active Comparator group

Description:

This group receives FIO2 \<0.7 during the surgery.

Treatment:

Other: fraction of inspired oxygen (FIO2)