Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation (FFBET)

Michael J. Ormsbee

Status: Completed

Conditions: Body Temperature Changes; Inflammation; Body Water Dehydration

Treatments: Dietary Supplement: Betaine; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06042270

STUDY00004218

Details and patient eligibility

About

The goal of this clinical trial is to compare betaine supplementation to placebo in firefighters undergoing live burn training regarding thermoregulation and inflammation. The main questions it aims to answer are:

• Does betaine supplementation mitigate rises in core temperature during firefighter live burn training?
• Does betaine supplementation decrease inflammation from firefighter training?
• Does betaine supplementation increase total body water stores?

Participants will supplement with betaine for 1 month and complete:

• Total Body Water measures
• Body Composition measures
• Live Burn training with Core Temperature Measurements
• Provide Salivary samples

Enrollment: 17 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Structural Firefighter

Exclusion criteria

• • Participants have a cardiometabolic disease for which they take prescribed medications

  • Participants consume supplements known to impact hydration status or performance that they are not willing to stop taking for the study
  • Participants are pregnant
  • Female participants that have irregular menstrual cycles
  • Participants are injured and would not be able to fulfill the live burn scenario
  • Participants have sickle cell disease
  • Participants have experienced heat stroke within the last 2 years

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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17 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

10 participants will be given rice-flour as a placebo

Treatment:

Dietary Supplement: Placebo

Betaine

Active Comparator group

Description:

10 participants will be given betaine

Treatment:

Dietary Supplement: Betaine