First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

DualityBio

Status and phase: Enrolling; Phase 2; Phase 1

Conditions: Solid Tumor, Adult

Treatments: Drug: DB-1419

Study type: Interventional

Funder types: Industry

Identifiers

NCT06554795

DB-1419-O-1001

Details and patient eligibility

About

A Phase 1/2a First-in-Human Study of DB-1419 in Advanced/Metastatic Solid Tumors

Full description

A Phase 1/2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1419 in Participants with Advanced/Metastatic Solid Tumors

Enrollment: 360 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adults aged ≥ 18 years at the time of voluntarily signing informed consent.

2. Histologically or cytologically confirmed unresectable advanced/metastatic solid tumor that has relapsed or progressed on or after standard systemic treatments, or refused the standard treatment, or for which no standard treatment is available.

3. At least one measurable lesion as assessed by the Investigator according to RECIST v1.1 criteria (Only applicable to backfill participants in phase 1a and participants in phase 1b/2a). CRPC participants with bone-only disease may be eligible on a case-by-case basis after discussion with the Medical Monitor.

4. Has a life expectancy of ≥ 3 months.

5. Has an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-1.

6. Has LVEF ≥ 50% by either echocardiography (ECHO) or multiple-gated acquisition (MUGA) within 28 days before enrollment.

7. Has adequate organ function within 7 days prior to the first dose of study treatment.

8. Has adequate treatment washout period prior to the first dose of study treatment.

9. Is willing to provide pre-existing resected tumor samples when available or undergo fresh tumor biopsy if feasible for the measurement of B7-H3/PD-L1 level and other biomarkers if no contraindication.

   Note: there is no minimum B7-H3/PD-L1 expression level mandatory for entry into the study.

10. Is capable of comprehending study procedures and risks outlined in the informed consent and able to provide written consent and agree to comply with the requirements of the study and the schedule of assessments.

Exclusion criteria

1. Prior treatment with B7-H3 targeted therapy.
2. Has a medical history of symptomatic congestive heart failure (New York Heart Association [NYHA] classes II-IV or serious cardiac arrhythmia requiring treatment.
3. Has a medical history of myocardial infarction or unstable angina within 6 months before enrollment.
4. Has an average of Fredericia's formula-QT corrected interval (QTcF) prolongation to > 470 millisecond (ms) in males and females based on a 12-lead electrocardiogram (ECG) in triplicate.
5. Has a medical history of interstitial lung diseases (e.g., non-infectious interstitial pneumonia, pneumonitis, pulmonary fibrosis, and severe radiation pneumonitis which needs glucocorticoids and antibiotics) or current interstitial lung diseases or who are suspected to have these diseases by imaging at screening.
6. Has a history of underlying pulmonary disorder including, but not limited to, pulmonary emboli within 3 months of the start of study treatment, severe asthma, severe COPD, restrictive lung disease, and other clinically significant pulmonary compromise or requirement for supplemental oxygen.
7. Has an active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is allowed.
8. Has an uncontrolled infection requiring intravenous injection of antibiotics, antivirals, or antifungals within 2 weeks before first dose of study treatment.
9. Know human immunodeficiency virus (HIV) infection.
10. Has spinal cord compression or clinically active central nervous system (CNS) metastases, defined as untreated and symptomatic, or requiring therapy with corticosteroids or anticonvulsants to control associated symptoms. Participants with asymptomatic CNS metastases who are radiologically and neurologically stable for at least 4 weeks following CNS-directed therapy (defined as 2 brain images, same imaging modality, both of which are obtained after treatment to the brain metastases; these imaging scans should be obtained at least 4 weeks apart and show no evidence of intracranial progression), and are on stable or decreasing doses of corticosteroids equivalent to ≤10 mg/day prednisone are eligible for study entry.

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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360 participants in 14 patient groups

Dose Level 1

Experimental group

Description:

Enrolled subjects will receive DB-1419 at Dose Level 1

Treatment:

Drug: DB-1419

Dose Level 2

Experimental group

Description:

Enrolled subjects will receive DB-1419 at Dose Level 2

Treatment:

Drug: DB-1419

Dose Level 3

Experimental group

Description:

Enrolled subjects will receive DB-1419 at Dose Level 3

Treatment:

Drug: DB-1419

Dose Level 4

Experimental group

Description:

Enrolled subjects will receive DB-1419 at Dose Level 4

Treatment:

Drug: DB-1419

Dose Level 5

Experimental group

Description:

Enrolled subjects will receive DB-1419 at Dose Level 5

Treatment:

Drug: DB-1419

Dose Level 6

Experimental group

Description:

Enrolled subjects will receive DB-1419 at Dose Level 6

Treatment:

Drug: DB-1419

Dose Expansion 1

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 2

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 3

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 4

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 5

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 6

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 7

Experimental group

Treatment:

Drug: DB-1419

Dose Expansion 8

Experimental group

Treatment:

Drug: DB-1419