First-in-man Dose Escalation Study of BAY2010112 in Patients With Prostate Cancer

Bayer

Status and phase

Completed

Phase 1

Conditions

Prostatic Neoplasms

Treatments

Biological: BAY2010112

Study type

Interventional

Funder types

Industry

Identifiers

NCT01723475

15590 (Other Identifier)

2012-000691-42 (EudraCT Number)

Details and patient eligibility

About

This is the first study where BAY2010112 is given to humans. Patients with castration resistant prostate cancer will be treated. Every patient will receive drug treatment, there is no placebo group. Patients will receive different dosages of BAY2010112 to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY2010112.

The study will also assess the pharmacokinetics and the clinical efficacy of BAY2010112.

BAY2010112 will be given daily as subcutaneous injection or as continuous intravenous infusion. Treatment will be stopped if the tumor continues to grow, if side effects, which the patient cannot tolerate, occur or if the patient decides to exit treatment.

Enrollment

47 patients

Sex

Male

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male subjects, aged >/= 18 years
Subjects with histologically or cytologically proven advanced castration-resistant prostate cancer (CRPC)
- who failed at least 1 taxane regimen and are refractory to abiraterone and/or enzalutamide therapy OR
- who have actively refused any treatment which would be regarded standard.
Subjects should have undergone bilateral orchiectomy or should be on continuous androgen deprivation therapy with a gonadotropin releasing hormone agonist or antagonist.
Subjects must have shown progressive disease after discontinuation of anti-androgen therapy (i.e. flutamide, bicalutamide or nilutamide) before study drug treatment.
Total serum testosterone should be less than 50 ng/ml or 1.7 nmol/L
Evidence of progressive disease, defined as one or more (Prostate Cancer Working Group 2 (PCWG2) criteria):
PSA level of at least 2 ng/ml that has risen on at least 2 successive occasions at least 1 week apart
Nodal (in lymph nodes >/= 2cm) or visceral progression as defined by Response Evaluation Criteria in Solid Tumors (RECIST)
Appearance of one more new lesions in bone scan
Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2
Life expectancy of at least 3 months

Exclusion criteria

Any anticancer therapy or immunotherapy within 4 weeks of start of first dose
Confirmed history or current autoimmune disease or other diseases resulting in permanent immunosuppression or requiring permanent immunosuppressive therapy
Prior radiotherapy (local palliative radiotherapy is permitted)
History of allergic reactions to monoclonal antibody therapy
History of clinical significant cardiac disease: including unstable angina, acute myocardial infarction within 6 months prior to first study treatment, congestive heart failure ≥New York Heart Association (NYHA) Class III), and arrhythmia requiring therapy except for beta-blockers, calcium channel blockers and digoxin or uncontrolled hypertension, despite optimal medical management
Clinically relevant findings in the electrocardiogram (ECG) such as a second- or third-degree AV block, prolongation of the QRS complex over 120 msec or of the QT interval corrected for heart rate (QTc)-interval over 450 msec
Current evidence or history of uncured (i.a. any absolute risk of latent infection) of hepatitis B or C or human immunodeficiency virus (HIV) infection
Chronic systemic corticosteroid therapy or any other immunosuppressive therapies should have been stopped at screening start
Seizure disorder requiring therapy (such as steroids or anti-epileptics)
Subjects unable to inject the study drug subcutaneously for intended s.c. application
Non-suitable for a central venous access for intended c.i.v. administration