Fixed Versus Flexible Gonadotropin-releasing Hormone (GnRH) Antagonist Initiation

Aristotle University Of Thessaloniki

Status and phase: Completed; Phase 4

Conditions: Subfertility

Treatments: Drug: Cetrorelix (Cetrotide)

Study type: Interventional

Funder types: Other

Identifiers

NCT01005784

UHR-3

Details and patient eligibility

About

This is a comparison of pregnancy achievement between two GnRH antagonist protocols which differ in the timing of GnRH antagonist initiation.

Enrollment: 146 patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• < 39 years of age
• BMI 18.5-29.9
• <= 3 previous IVF cycles

Exclusion criteria

• PCOS
• Endometriosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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146 participants in 2 patient groups

fixed

Active Comparator group

Treatment:

Drug: Cetrorelix (Cetrotide)

Drug: Cetrorelix (Cetrotide)

flexible

Experimental group

Treatment:

Drug: Cetrorelix (Cetrotide)

Drug: Cetrorelix (Cetrotide)