Flavanol-Rich Cocoa and Cerebral Blood Flow

Mass General Brigham

Status: Completed

Conditions: Hypertension; Diabetes

Treatments: Dietary Supplement: cocoa

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00825695

1R01HL089570 (U.S. NIH Grant/Contract)

P-001936

Details and patient eligibility

About

The purpose of the study is to learn whether or not cocoa has a beneficial effect on blood flow to the brain in older subjects with diabetes mellitus or hypertension (high blood pressure). We hypothesize that cocoa, which contains flavanols (a type of polyphenol), may help to promote blood flow to the brain in older people with diabetes or hypertension.

Enrollment: 60 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diabetes and/or hypertension

Exclusion criteria

• alzheimers disease, dementia, stroke, recent angina or heart attack

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

flavanol-rich cocoa

Active Comparator group

Treatment:

Dietary Supplement: cocoa

flavanol-poor cocoa

Placebo Comparator group

Treatment:

Dietary Supplement: cocoa