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FLOTRAC/VIGILEO in Acute Circulatory Failure (FLOVAC)

H

Hôpital Européen Marseille

Status

Terminated

Conditions

Acute Circulatory Failure
Fluid Loading
Critically Ill

Treatments

Device: Flotrac/Vigileo third generation software
Device: Transthoracic echocardiography

Study type

Observational

Funder types

Other

Identifiers

NCT01090791
2009-A007419-48

Details and patient eligibility

About

Acute circulatory failure may be related to hypovolemia. Fluid loading increases stroke volume in approximatively half of challenges. Determining fluid responsiveness prevents unnecessary fluid loading. Passive leg raising (PLR) provides a transient increase of 300 ml in venous return for a short time. The measurement of stroke volume (SV) before and after a PLR test allows physician to detect fluid responsiveness, when stroke volume increases is higher than 15 %. Beside thermodilution, the use of non invasive device to measure stroke volume becomes largely employed. Arterial Pressure based Cardiac Output (APCO), provided by the Flotrac/Vigileo system, does not required specific materials nor repeated calibration. The third generation software is believed to be more accurate and more precise for SV measurement. The aim of this study is to test the performance of the Flotrac/Vigileo device in a situation of rapid venous return changes induced by PLR and then by fluid loading. Patients will be classify posteriorly in responders and non responders, according to the magnitude of the fluid loading-induced SV changes measured by transthoracic echocardiography.

Enrollment

1 patient

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Systolic arterial pressure < 90 mmHg or Mean arterial pressure < 60 mmHg
  • Heart rate > 100 bpm
  • Norepinephrine infusion
  • Urine output < 0.5 ml/kg/h during at least two consecutive hours
  • skin mottling
  • Capillary refill time > 3 sec

Exclusion criteria

  • Acute cor pulmonale
  • Ongoing renal replacement therapy
  • Lack of echogenicity during transthoracic echocardiography

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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