Fluid Balance and Clinical Outcomes

University of Florida

Status: Completed

Conditions: Mortality; Acute Kidney Injury; Inflammatory Mediators; Input and Output; Fluid Balance

Study type: Observational

Funder types: Other

Identifiers

NCT01168583

126-2010

Details and patient eligibility

About

This study is about investigating the relationship of postoperative fluid balance, inflammation and acute kidney injury. This is a non-interventional study (no drug administration). The investigators will collect baseline demographic data, postoperative fluid balance status by Intake-output data, follow routine labs and collect 1 blood sample (0.5ml) with morning lab draws on day 1 and 5ml urine samples on day 1 and 2.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older, and
• Undergoing elective cardiothoracic surgery(s), alone or in combination with other procedures/surgery(s): thoracic aortic aneurysm, cardiac valves, coronary artery bypass grafting, abdominal thoracic aneurysm, and other cardiovascular surgery.

Exclusion criteria

• Pregnancy
• History of any organ transplant
• Preoperative intra-aortic balloon pump (IABP)
• Current use of natriuretic peptides
• ESRD patients on dialysis
• Estimated GFR < 30ml/min using MDRD equation.

Trial design

300 participants in 2 patient groups

Positive Fluid Balance of 2000ml

Negative Fluid Balance of 2000ml