Fluid Balance During Closure of Atrial Septal Defect

University of Oslo (UIO)

Status: Completed

Conditions: Heart Defects,Congenital; Heart Septal Defects, Atrial

Study type: Observational

Funder types: Other

Identifiers

NCT01757743

063.09

Details and patient eligibility

About

This project will evaluate fluid balance and oedema formation in children with the same congenital heart disease (Atrial Septal Defect) who will either go through heart surgery with the use of Cardio Pulmonary Bypass and hypothermia or through interventional catheterization. The investigators will measure interstitial colloid osmotic pressure, distribution of proteins and cytokines. The study hypothesis is that "Oedema developed during heart surgery is caused by reduced colloid osmotic pressure gradient through the capillary membrane".

Enrollment: 41 patients

Sex: All

Ages: 6 months to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The diagnosis of Atrial Septal Defect scheduled for closure
• Informed consent

Exclusion criteria

• Renal failure,
• liver failure,
• coexisting cardiac malformations

Trial design

41 participants in 2 patient groups

Interventional closure

Description:

Interventional catheterization closure

Open Heart Surgery

Description:

Surgery for Atrial septal defect