Fluid Balance During Exercise in the Heat With Water, Flavored Placebo, or a Carbohydrate-electrolyte Beverage Intake (The APEX Study)

Pennington Biomedical Research Center

Status: Completed

Conditions: Dehydration

Treatments: Other: Exercise Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01893853

PBRC 12038

Details and patient eligibility

About

The purpose of the APEX study is to determine whether carbohydrate-electrolyte beverage intake promotes fluid balance during exercise in the heat compared with water or placebo intake.

Full description

Exercise in the heat has large effects on cardiovascular strain, the ability to regulate core body temperature, and performance because of an increase in the reliance on body fluid distribution to the skin to maintain adequate sweat rates and heat dissipation. Carbohydrate-electrolyte beverage intake during exercise in the heat may improve fluid balance and subsequent physical performance.

The participants will be assigned each arm in a randomized, counterbalanced, cross-over fashion separated by at least 2 weeks. Participants will be placed in a heated environment for the duration of the exercise intervention.

Enrollment: 24 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males aged 18-35 years
• Healthy (No uncontrolled disease)

Exclusion criteria

• No medications that influence fluid balance
• No uncontrolled disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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24 participants in 3 patient groups, including a placebo group

Water

Other group

Description:

Electrolyte- and mineral-free water with exercise intervention

Treatment:

Other: Exercise Intervention

Placebo

Placebo Comparator group

Description:

Calorie- and electrolyte-free, sweetened flavored water with exercise intervention

Treatment:

Other: Exercise Intervention

Carbohydrate-electrolyte beverage

Experimental group

Description:

Commercially-available flavored beverage carbohydrate-electrolyte beverage with Exercise Intervention

Treatment:

Other: Exercise Intervention