Fluid Infusion During Breast Surgery

Rigshospitalet

Status and phase

Unknown

Phase 4

Conditions

Breast Surgery

Treatments

Drug: Hydroxyethylstarch 130/0,4

Drug: Lactated Ringer's solution

Study type

Interventional

Funder types

Other

Identifiers

NCT00431743

Mastectomy opti.

Details and patient eligibility

About

The investigators want to investigate the effects of two different kinds of fluid infusions given during varicose vein surgery. Both types of fluid are regularly given during surgery, and the investigators want to compare their respective effects on balance, nausea/vomiting and orthostatic function after surgery.

The investigators' hypothesis is that using a colloid solution will improve orthostatic function, balance, nausea/vomiting and reduce hospital stay.

Full description

The optimal amount and type of fluid given during surgery has not been defined. It has been agreed that hypovolemia must be avoided, but at the same time it has been agreed that fluid excess is harmful for organ function.When distributing fluids it is usually either crystalloids og colloids which are given. The effects of the two types of fluid have not been compared. Our hypothesis is that using a colloid (HES 130/0,4) will improve orthostatic function, nausea/vomiting and shorten hospital stay, compared to using a crystalloid (Lactated Ringer's solution).The amount of fluid the patient receives, will be individually tailored by monitoring SV using esophageal Doppler technique during surgery.

Enrollment

32 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients having performed elective breast surgery.
Age between 18 and 70 years
Patients who have given written consent to participate in the project after haven completely understood the contents and limitations of the protocol.

Exclusion criteria

Patients who do not understand or speak Danish
Patients who have not signed the informed consent or the written authority
pre-medication, except 1g paracetamol
ASA > II
Pregnant or breastfeeding
Known to have Renal disease
Known to have Psychiatric disorder (not considering the use of SSRI antidepressive)
Need for crash induction or prone position.
Oesophageal varicoses
Necrosis or cancer in: Mouth, Pharynx, Larynx or Oesophagus
Coarctation or aneurism in the proximal Aorta
Severe bleeding disease