Fluid Intake in Kidney Failure

Medical University of Vienna

Status: Completed

Conditions: Kidney Transplantation; Chronic Renal Failure

Treatments: Behavioral: high fluid intake; Behavioral: normal fluid intake

Study type: Interventional

Funder types: Other

Identifiers

NCT00842322

OFS1

Details and patient eligibility

About

Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation. In contrast,high fluid intake could be dangerous if urine excretion is reduced. In this study the researchers investigate whether increasing fluid intake from 2 to 4 litres per day has any influence on long-term renal outcome.

Enrollment: 76 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with native kidney disease or chronic kidney transplant failure
• An effective glomerular filtration rate (eGFR) according the MDRD formula between 20 and 75ml/min/1.73m2
• Ejection fraction >20%
• Absence of liver cirrhosis or ascites
• No evidence of active glomerulonephritis or immunosuppressive therapy if native kidney disease
• Acute transplant rejection
• Urinary protein excretion below 3g/d
• Age between 18 and 70 years.

Exclusion criteria

• Therapy resistant edema
• Severe pulmonary disease
• Mean arterial pressure (MAP) > 120 mm Hg
• Pregnancy
• Kidney transplantation within three months prior to randomization

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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76 participants in 2 patient groups

High fluid intake

Experimental group

Description:

fluid intake of 4 litres per day

Treatment:

Behavioral: high fluid intake

normal fluid intake

Experimental group

Description:

Fluid intake of 2 litres per day

Treatment:

Behavioral: normal fluid intake