Fluid Investigation Colloid vs Crystalloid Reg. Renal Hemodynamics and Function

Sahlgrenska University Hospital

Status: Completed

Conditions: Renal Impairment

Treatments: Drug: colloid; Drug: crystalloid

Study type: Interventional

Funder types: Other

Identifiers

NCT01729364

vätskestudien

Details and patient eligibility

About

Comparing the effects of crystalloid versus colloid fluid resuscitation in CABG patients postoperatively regarding renal blood flow, glomerular filtration rate and renal oxygen demand.

Full description

Due to blood loss and SIRS postoperative hypovolemia is a usual feature after CABG surgery. Substantial controversy persists regarding the best choice of fluid to be used for resuscitation in this setting regarding renal function and oxygen supply-demand matching. In our study we aim to investigate differences in functional renal parameters by dividing patients postoperatively in two groups, substituted either with crystalloid fluid, Ringer-Acetat, 20 ml/kg or colloid, HES 6% (130/0,4) 10 ml/kg under 20 minutes. Central and renal hemodynamics will be measured before (baseline) and after fluid administration by blood sampling and thermodilution in both pulmonary artery catheter and renal vein catheter. Measurement endpoints will mainly consist of central hemodynamics, renal blood flow, GFR and renal oxygen extraction rate which we aim to compare between groups.

Enrollment: 30 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective fast track CABG patients, postoperative

Exclusion criteria

• hemodynamic instability
• preoperative renal impairment
• major postoperative bleeding

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

crystalloid

Experimental group

Description:

crystalloid fluid administration, Ringer-acetat 20ml/kg under 30 minutes

Treatment:

Drug: crystalloid

colloid

Experimental group

Description:

colloidal fluids administration, HES 6% (130/0,4) 7ml/kg under 30 minutes

Treatment:

Drug: colloid