Fluid Management Strategies on Blood Loss in Liver Transplantation

National Taiwan University

Status: Enrolling

Conditions: Liver Transplant

Treatments: Other: Liberal group; Other: restrictive group

Study type: Interventional

Funder types: Other

Identifiers

NCT06215404

202308015MINC

Details and patient eligibility

About

During liver transplantation, due to the complexity of the operation and abnormal coagulation function, there may be a large amount of bleeding and corresponding blood transfusion. Excessive blood transfusion will increase pulmonary complications and affect the prognosis. Infusion management to reduce bleeding is a very important issue in liver transplant surgery. Restrictive infusion management can effectively reduce the amount of bleeding in liver transplantation, but it remains unclear whether it will cause sequelae in other major organs.

The investigators plan to study different infusion goals and strategies in liver transplant surgery using a randomized group model, using the PiCCO (Pulse Contour Cardiac Output) cardiopulmonary volume monitor, and setting the stroke volume variation (SVV) as the macroscopic circulation.The purpose of this study was to divide it into restrictive and liberal groups to explore the impact on liver transplantation bleeding volume and inflammatory response as well as postoperative lung and renal function, and to collect statistics on clinical care and postoperative sequelae (pulmonary liver, renal function impairment, etc.) in order to develop the most appropriate infusion management strategy in liver transplantation.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• end stage liver disease
• age between 18y/o to 75 y/o
• expected to recieve to receive liver transplantation

Exclusion criteria

• arrythmia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Liberal group

Active Comparator group

Description:

stroke volume variation \< 10%

Treatment:

Other: Liberal group

restrictive group

Experimental group

Description:

stroke volume variation \< 18%

Treatment:

Other: restrictive group