Fluid Responsiveness Prediction Using Extra Systoles

University of Aarhus

Status: Completed

Conditions: Fluid Responsiveness

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02520037

University of Aarhus

Details and patient eligibility

About

Fluids are generally administered to patients in order to improve circulation. However, fluids do not always improve circulation and fluids have side effects. Unfortunately, it is difficult to predict whether fluid administration improves the circulation, i.e. it is difficult to predict fluid responsiveness The overall aim of this observational study is to investigate if analysis of spontaneously occuring extra systoles can give the answer: The second beat in the extra systole - the post ectopic beat - is a normal sinus beat but it has experienced the compensatory pause, i.e. this beat is associated with increased filling time and in turn associated with increased filling. As such, the post ectopic beat shows how the heart responds to increased filling. Therefore, the hypothesis of this study is that the hemodynamic response to the increased filling at the post ectopic beat (compared with sinus beats) can predict fluid responsiveness

Enrollment: 26 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for a 500 ml volume expansion
• Patients without atrial fibrillation
• Patients equipped with ECG, arterial pressure and non-invasive cardiac output monitoring

Exclusion criteria

• Changes in anesthetic, vasoactive or inotropic drugs during the study period (30 minutes before fluid infusion initiation to end of fluid infusion).
• Changes in positive end-expiratory pressure the study period
• Changes in bed positioning the study period
• Infusion time with crystalloids exceeding 30 minutes
• Infusion time with colloids exceeding 75 minutes