FLuid Responsiveness Prediction Using EXtra Systoles

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Coronary Artery Bypass Graft

Treatments: Other: fluid challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT03002129

FLEx study

Details and patient eligibility

About

In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.

Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids

Enrollment: 60 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients requiring elective CABG or OPCAB surgery
• Patient's age ≥ 18 years

Exclusion criteria

• Patient refusal
• Pregnancy
• EF < 35%
• End stage kidney failure (defined by the need for haemodialysis)
• Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

fluid challenge

Other group

Treatment:

Other: fluid challenge