Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury

University of Zurich (UZH)

Status and phase: Completed; Phase 3

Conditions: Survival; Renal Failure

Treatments: Drug: Fluid resuscitation; Drug: fluid resuscitation

Study type: Interventional

Funder types: Other

Identifiers

NCT01120730

USZ-BURN

97/x (Other Identifier)

Details and patient eligibility

About

HES 200/0.5 10% is equal to ringers lactat solution.

Full description

30 Patients were enrolled to the study, either to the hyperoncotic HES 200/0.5 (10%) group or to the crystalloids only group. After a treatment protocol of 72 hours we collected data about complications like pulmonary failure and abdominal compartment syndrome. Furthermore, we addressed the question of incidence of mortality and renal failure.

Enrollment: 28 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All burn victims with burned surface area bigger than 20%

Exclusion criteria

• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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28 participants in 2 patient groups, including a placebo group

HES

Active Comparator group

Description:

Fluid resuscitation with HES

Treatment:

Drug: fluid resuscitation

ringers lactat

Placebo Comparator group

Description:

Standard treatment

Treatment:

Drug: Fluid resuscitation