Flurbiprofen Axetil for Uterine Contraction Pain (FAUCOP)

Nanjing Medical University

Status and phase: Completed; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Saline; Drug: Flurbiprofen Axetil

Study type: Interventional

Funder types: Other

Identifiers

NCT00725218

NMU-MZ203

M089732

Details and patient eligibility

About

Uterine contraction pain is a common problem after abortion. Optimal analgesic for such suffering is still needed to be guaranteed. Flurbiprofen Axetil is a target-distributable non-steroidal anti-inflammatory drug (NSAID) functioning via block the synthesis of prostaglandin E (PGE). The investigators hypothesized that Flurbiprofen Axetil could suppress the uterine contraction pain after abortion effectively.

Enrollment: 97 patients

Sex: Female

Ages: 19 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA status I-II
• Performing abortion operation (medical- or drug-induced
• Requiring painless abortion

Exclusion criteria

• < 19yrs, and >= 45yrs
• History of central active drugs administration
• Drug abuse
• Hypertension
• Diabetes
• Any other chronic diseases
• Allergy to the study drugs
• Habit of over-volume alcohol drinking
• Records of history of centrally active drug use and psychiatry
• Any organic disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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97 participants in 2 patient groups, including a placebo group

1

Placebo Comparator group

Description:

Saline 5 ml injection 10 min prior to propofol administration.

Treatment:

Drug: Saline

2

Experimental group

Description:

Flurbiprofen Axetil 50 mg in 5 ml injection 10min prior to propofol administration.

Treatment:

Drug: Flurbiprofen Axetil