fMRI Cholinergic Mechanisms in Schizophrenia

US Department of Veterans Affairs (VA)

Status: Completed

Conditions: Schizophrenia

Study type: Observational

Funder types: Other U.S. Federal agency

Identifiers

NCT01191827

MHBB-011-07F

Details and patient eligibility

About

This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.

Full description

This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.

Enrollment: 40 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of schizophrenia
• age 18-60 yrs

Exclusion criteria

• claustrophobia
• weight > 250 lbs
• metal in body other than dental fillings

Trial design

40 participants in 2 patient groups

risperidone

clozapine

Description:

Patients with schizophrenia treated with clozapine