fMRI Connectivity in Fracture Hip Patients

University of Florida

Status: Completed

Conditions: Postoperative Delirium; Postoperative Cognitive Dysfunction

Treatments: Behavioral: Wide Range Achievement Test reading subtest; Behavioral: General Depression Scale (GDS); Behavioral: Montreal Cognitive Assessment (MoCA); Behavioral: Digital Clock Drawing Test Command and Copy; Behavioral: fMRI; Behavioral: Hopkins Verbal Learning Test (HVLT)

Study type: Interventional

Funder types: Other

Identifiers

NCT02997930

IRB201601806

OCR18886 (Other Identifier)

Details and patient eligibility

About

The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.

Full description

In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.

Enrollment: 2 patients

Sex: All

Ages: 65 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 65 years and older
• Patients who have fracture hip and are anticipated to have surgery

Exclusion criteria

• Patients who have contraindications for MRI like pacemaker, automatic implanted cardiac defibrillator (AICD), implanted infusion pumps etc.
• Patients who are claustrophobic
• Patients with severe cognitive impairment (who may not be able to cooperate during the cognitive exam and fMRI)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

Elderly Hip Fracture

Experimental group

Description:

Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)

Treatment:

Behavioral: Wide Range Achievement Test reading subtest

Behavioral: Hopkins Verbal Learning Test (HVLT)

Behavioral: Digital Clock Drawing Test Command and Copy

Behavioral: fMRI

Behavioral: Montreal Cognitive Assessment (MoCA)

Behavioral: General Depression Scale (GDS)