fMRI in Blood Phobia Syncope

Vanderbilt University

Status: Withdrawn

Conditions: Syncope; Blood Injury Phobia; Autonomic Dysfunction

Treatments: Procedure: fMRI Scan

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00715065

NIH UL1 RR024975

080608

Details and patient eligibility

About

We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain activation in response to seeing bloody or gory pictures that occur before the fainting occurs.

Full description

Another aim of the study is to determine whether or not differences in personality traits among people with blood phobia is associated with differences in BOLD signal responses during fMRI.

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-30 years of age
• 1. History of at least one syncopal episode upon exposure to viewing blood (Case Group)
• Negative urine pregnancy test on study day

Exclusion criteria

• Vasoactive medications (within 2 weeks of study day)
• antihypertensives
• beta blockers
• vasoconstrictors
• Psychotropic medications (within 4 weeks of study day)
• History of psychostimulant or opiate use
• History of alcohol, benzodiazepine or cannabis abuse or dependence

Trial design

0 participants in 2 patient groups

2

Description:

Healthy control subjects (who do not faint at the sight of blood)

Treatment:

Procedure: fMRI Scan

1

Description:

People who faint at sight of blood

Treatment:

Procedure: fMRI Scan