fMRI in Deep Brain Stimulation

Universitaire Ziekenhuizen KU Leuven

Status: Enrolling

Conditions: Epilepsy; Chronic Pain

Treatments: Diagnostic Test: fMRI

Study type: Interventional

Funder types: Other

Identifiers

NCT03819738

S60058

Details and patient eligibility

About

With fMRI, we want to understand the mechanisms of brain neuromodulation in (dys)functional brain circuits, to obtain knowledge on involved brain networks in DBS.

Full description

Deep brain stimulation represents a neurosurgical treatment option for specific refractory neurological and psychiatric disorders. In these patients a specific brain target is stimulated through an electrode with the use of an implantable pulse generator (IPG). In a functional MRI (fMRI) experiment, the investigators intend to perform imaging during stimulation ON and compare brain activations with the stimulation OFF condition. In this way, they aim to elucidate the involved brain network in deep brain stimulation. Since the connectivity of deep brain structures is complex, different activation patterns are expected in-between subjects and conditions. If specific activation patterns during the stimulation ON condition can be related to treatment response, this is of important clinical value. These findings can lead to an optimization of the deep brain target or even to different useful targets for brain stimulation.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Deep brain stimulation system implanted

Exclusion criteria

• Children and pregnant women will be excluded. Failure to follow to protocol is also an exclusion criterion.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

fMRI intervention

Experimental group

Treatment:

Diagnostic Test: fMRI