fMRI Study of the Neural Mechanism of rTMS in the Treatment of Nicotine Dependence

Tang-Du Hospital

Status: Active, not recruiting

Conditions: Tobacco Use Disorder; Repetitive Transcranial Magnetic Stimulation

Treatments: Device: repetitive transcranial magnetic stimulation; Device: Sham repetitive transcranial magnetic stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT06762535

nicotine dependence

Details and patient eligibility

About

The goal of this clinical trial is to investigate the efficacy of treatment and the efficacy-related neural network mechanisms by stimulating the left dorsolateral prefrontal lobe with rTMS to nicotine dependent.

The main questions it aims to answer are:

• Efficacy of left dorsolateral prefrontal rTMS in the treatment of nicotine dependent subjects.
• The relationship between therapeutic effect and the internal function of the large brain networks of ECN, DMN and SN, and the changes in the interaction between the networks.

Full description

Participants will randomly divided into two groups，Relevant psychological and behavioral data and fMRI data were collected first, and then rTMS was continuously treated for 2 weeks. The above data were collected again after the treatment ended, and then the follow-up was conducted for 1 month. Psychobehavioral data were collected once a week for nicotine addicts.Finally, the collected neuroimage data were analyzed to compare the difference in efficacy between the true and false treatment groups, and to clarify the relationship between the efficacy of nicotine dependent patients after rTMS treatment and the internal functions of the large brain networks of ECN, DMN and SN as well as the interaction characteristics of the networks, so as to provide a scientific basis for the development of effective individualized treatment programs.

Enrollment: 50 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Meets the DSM-V diagnostic criteria for addiction
• Pure nicotine dependence
• Did not receive medication
• Right-handed

Exclusion criteria

• Patients with organic brain lesions and a history of severe head trauma
• Compliance is poor
• Multiple drug abusers
• Current or past history of mental or neurological disorders
• There was a metallic foreign object in his body
• People with pacemakers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 3 patient groups

Active repetitive transcranial magnetic stimulation

Active Comparator group

Description:

Intervention type:Pulse field stimulator of shenzhen yingzhi co., LTD The RTMS treatment target is scheduled for the lateral frontal lobe on the left side. The TMS stimulation frequency is 10Hz, and the stimulation intensity is 100% of the motion threshold 5s, off 10s, for 10 minutes, 2,000 pulses.

Treatment:

Device: repetitive transcranial magnetic stimulation

Sham repetitive transcranial magnetic stimulation

Sham Comparator group

Description:

Intervention type:Pulse field stimulator of shenzhen yingzhi co., LTD The RTMS treatment target is scheduled for the lateral frontal lobe on the left side. The TMS stimulation frequency is 10Hz, and the stimulation intensity is 100% of the motion threshold 5s, off 10s, for 10 minutes, 2,000 pulses.But there's no real pulse output,Just set the same conditions.

Treatment:

Device: Sham repetitive transcranial magnetic stimulation

No repetitive transcranial magnetic stimulation

No Intervention group

Description:

No treatment with a transcranial magnetic stimulator