FMT Treating Constipation Patients With Depression and/or Anxiety Symptoms - Clinical Efficacy and Potential Mechanisms

Jianfeng Gong

Status

Unknown

Conditions

Depressive Symptoms

Anxiety Symptoms

Gut-Brain Disorders

Constipation - Functional

Treatments

Other: FMT

Study type

Interventional

Funder types

Other

Identifiers

NCT03233100

STC-D-A-2017-FMT

Details and patient eligibility

About

Constipated patients often have mental problems such as depression and anxiety due to difficult defecation. Our previous studies have proved the efficacy of FMT treating constipation. Meanwhile it is believed that mental diseases are correlated to gut microbiota. This trial is based on the theory of the gut-brain-microbiota axis. Patients with constipation, depression and/or anxiety are performed FMT, laboratory, imaging and microbiota examinations, and clinical follow-up, to observe the clinical efficiency of FMT and the potential role of gut microbiome in these gut-brain disorders.

Enrollment

40 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients who were diagnosed as functional constipation (FC) according to Rome Ⅳ criteria were enrolled.
Age ≥ 18 years
Body mass index of 18-25 kg/m2.
HAMA ≥ 14 and/or HAMD (17 items) ≥ 17

Exclusion criteria

History of sever mental disorders such as schizophrenia and bipolar disorder
History of organic intestinal disorders
History of gastrointestinal surgery
Pregnant or breast-feeding women
Infection with enteric pathogen
Usage of probiotics, prebiotics, antibiotics within the last month
Uncontrolled hepatic, renal, cardiovascular, and respiratory, or any diseases that in the opinion of the investigator, could affect intestinal transit and the intestinal microbiota.
Patients who could not complete the follow-up