Focal Cortical Atrophy After Myocardial Internal Capsule (ACFI)

Toulouse University Hospital

Status

Completed

Conditions

Ischemic Stroke

Treatments

Other: Additional MRI

Study type

Interventional

Funder types

Other

Identifiers

NCT01862172

HAO 2012 (Other Identifier)

12 486 03

Details and patient eligibility

About

Primary purpose of the trial is to demonstrate the arisen of focal cortical atrophy, localized in the ipsilateral primary motor area, measured in mm, three months after infarction of internal capsule.

The patient is compared to himself between day zero to ten and three months.

The study hypotheses are:

A focal cortical atrophy of the ipsilesional primary motor area occurs after cerebral infarction of the internal capsule. It is measurable accurately and reproducibly by MRI at three months. Other brain areas within the voluntary motor system will also be explored (supplementary motor area, pre motor area).
This atrophy is correlated with achievement of pyramidal tract, assessed by the fractional anisotropy of its fibers.
This atrophy is correlated with disability at three months, assessed by Rankin score.

Full description

Twenty-two patients with ischemic stroke, subcortical, involving the internal capsule, will be included.

Each patient will be compared to himself, on day zero to ten and three months.

An MRI will be performed between day zero and ten, then three months of infarction sequences with traditional threeD enabling acquisition and tractography and The measurement of cortical thickness is in mm The measurement of fractional anisotropy of the pyramidal tract A clinical evaluation will be done between Day zero and Day ten then three months, using a neurological score (NIHSS), a score of functional disability (Rankin) and more analytical and sensitive tests such as dynamometer, the Finger Tapping test and test new plugs.

Enrollment

21 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients of 18 to 90 years old.
Subcortical stroke
Achievement of the internal capsule, according to MRI
Ability to perform MRI within 10 days after the onset of symptoms
NIHSS over or equal 2 and < 20
Rankin Score over or equal 1 and ≤ 5
Written informed consent after information about the protocol, from patients or reliable person if patient is in incapacity to sign
Affiliation to a social security scheme

Exclusion criteria

Pregnant or nursing women
Other cerebral lesion, concomitant or preexisting
Concomitant disease causing unfavorable prognosis within 3 months after inclusion
pre-existing psychiatric illness
Alcoholism or other chronic intoxication
Cortical localization of the infarction
Patient in a coma, who cannot be examined and evaluated
Patient intubated, ventilated, sedated
Cerebral hemorrhage, intra-parenchymal and / or subarachnoid
Persons protected by law (guardianship, curators and judicial protection)
Contraindications to magnetic resonance examination: pacemaker, metal implants, neurostimulators, Clips neurosurgical wire sutures, staples, metal heart valves, ventricular bypass valve, metal workers, foreign eye, shrapnel, bullet , cochlear implants