Follicular Challenge Test to Predict Response to GnRH Agonist Triggering

Shamir Medical Center (Assaf-Harofeh)

Status: Unknown

Conditions: Infertility, Female

Treatments: Other: Decapeptyl

Study type: Interventional

Funder types: Other

Identifiers

NCT04973969

0304-20-ASF

Details and patient eligibility

About

GnRH agonist triggering is used during ART in order to reduce the risk of OHSS. Some studies described that in up to 5% of the cycles triggered with GnRH agonist, a lack of respone or suboptimal response was displayed.

The investigators aim to asses the possibility to predict the respone to ovulation triggering by the response to decapeptyl in the follicular phase of the same cycle.

Full description

The investigators will use Decapeptyl on day 2 of menstruation followed by antagonist protocol.

Hormonal proflie including E2, P, LH, FSH will be measured. LH surge and the rest of the hormonal profile will be compared to day after ovulation triggering.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 41 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients that undergo fertility preservation

  • patients planned to freeze embryos due to PGT or surrogacy --patients at high risk for OHSS

Exclusion criteria

• Poor ovarian response
• known hypothalamic- pituitary dysfunction

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

study group

Other group

Description:

The participants will recieve decapeptyl 0.2 mg on day 2/3 of the follicular phase.At that day, and at the day after, hormonsl profile will be documented. The hormonal profile of the day after follicular decapeptyl administration will be compared to the hormonal profile to test the predictive value.

Treatment:

Other: Decapeptyl