Follicular Fluid Raman Shifts and IVF Outcomes

ShangHai Ji Ai Genetics & IVF Institute

Status: Unknown

Conditions: IVF; Polycystic Ovary Syndrome

Treatments: Diagnostic Test: Raman spectrum

Study type: Interventional

Funder types: Other

Identifiers

NCT04838535

JIAI E2019-09

Details and patient eligibility

About

This study intends to collect about 150 cases of follicular fluid samples from PCOS and non-PCOS infertility patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles (in clinical routines).We tend to detect Raman metabolic profile of the follicular fluid of the PCOS and non-PCOS groups, and find the correlation between the metabolic profile of the follicular fluid of PCOS patients and the oocyte quality, IVF outcome and subsequent embryo development are also under investigation. Metabolomics analysis was applied to look for markers of follicular fluid in PCOS patients, and further exploring data and strategies to improve the embryonic development potential and IVF outcome of PCOS patients.

Enrollment: 150 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients fit the Rotterdam criteria for PCOS
• Patients under IVF cycles

Exclusion criteria

• Patients with male factors infertility
• Patients with fallopian tube factors infertility

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

PCOS follicular fluid

Other group

Treatment:

Diagnostic Test: Raman spectrum