Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity

ART Fertility Clinics LLC

Status: Enrolling

Conditions: OVARIAN STIMULATION

Treatments: Other: transvaginal Ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT06839274

2408-ABU-013-AS

Details and patient eligibility

About

Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles.

Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 48 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Reproductive age group: 18 -48
• undergoing ovarian stimulation for oocyte vetrification
• undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr
• less than or equal to 3 AFC on initiation of stimulation
• follicular phase stimulation

Exclusion criteria

• surgically retrieved sperm

Trial design

100 participants in 1 patient group

The study population is the infertile patients seeking IVF treatment in ART fertility clinics of Abu

Description:

Recruited patients will be stimulated in a antagonist protocol with the use of Pergoveris as gonadotropin with a starting dose of 450 IU. The antagonist will be started on day 5 of the stimulation. Patients will be triggered according to clinical standard protocol for poor ovarian reserve patients when the leading follicle reaches 15 mm (2). The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time. Oocyte pickup will be performed the same way as per the SOP of the clinic for the patients who have less than 7 follicles on the day of the ovum pickup i.e. each follicle will be punctured, aspirated and then flu

Treatment:

Other: transvaginal Ultrasound