Follow-up of AKI in Neonates During Childhood Years (FANCY)

Matthew Harer, MD

Status: Unknown

Conditions: Childhood Chronic Kidney Disease; Neonatal Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT02306642

17540

Details and patient eligibility

About

The purpose of this study is to learn more about how to identify signs of early chronic kidney diseases in children who were born prematurely with low birth weight (less than 3 ½ pounds). Researchers plan to compare the kidney function in children who experienced acute kidney injury (AKI) in the Neonatal Intensive Care Unit (NICU) with those who did not experience it. Evidence from several studies and our experience at UVA show that older children who experienced AKI while in the Pediatric Intensive Care Unit (PICU) have increased risk of developing early chronic kidney disease, and they also show early changes in the urine and blood that is consistent with early chronic kidney disease. In this study, the investigators hope to determine if any of these changes can be detected in early childhood, and if so, at what age we can start detecting these changes.

Enrollment: 80 estimated patients

Sex: All

Ages: 2 to 7 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Premature birth for Premature groups
• UVA NICU admission prior to 2 days of life
• Birth weight less than 1500 grams for premature groups
• Premature AKI Study group: Acute Kidney Injury as defined by KDIGO modified criteria during NICU stay at UVA
• Premature no AKI Control group: No AKI during NICU stay
• Term no AKI Control group: No AKI and born at term
• Parental or legal guardian consent obtained

Exclusion criteria

• Patients with Congenital Anomalies of the Kidney and Urinary Tract

Trial design

80 participants in 3 patient groups

Premature Acute Kidney Injury in NICU

Description:

This group of babies born less than 1500 grams will have experienced acute kidney injury based on the modified KDIGO guidelines for acute kidney injury.

Premature No Acute Kidney Injury in NICU

Description:

This group of babies born less than 1500 grams will have not experienced acute kidney injury in the NICU.

Term No Acute Kidney Injury

Description:

This group of babies born at term will have not experienced any acute kidney injury.