Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based Study

University of Aarhus

Status: Completed

Conditions: Neonatal Hyperbilirubinemia

Treatments: Procedure: Movement assessment battery for children - 2

Study type: Observational

Funder types: Other

Identifiers

NCT01599611

pkv

Details and patient eligibility

About

The objective of this study was to investigate whether infants with total serum bilirubin > 450 umol/L in the neonatal period and no symptoms or no more than early acute bilirubin encephalopathy develop long term sequelae with impairment of motor development, hearing and executive function compared with a control group.

Full description

Children in both the exposed and the non-exposed group were examined by use of the MABC-2 and pure tone audiometry by the responsible examiner for the study, Pernille Vandborg, MD. The aim was to see whether the exposed group suffered any long term sequelae to the extreme neonatal hyperbilirubinemia, i.e. impaired motor development or hearing impairment, compared to a control group. The examinations took place at the local hospital.

Enrollment: 128 patients

Sex: All

Ages: 5 to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age > 35 weeks
• Total serum bilirubin > 450 umol/L in the neonatal period
• Born in the period 01.01.2000 - 31.12.2005

Exclusion criteria

• Acute intermediate or advanced bilirubin encephalopathy

Trial design

128 participants in 2 patient groups

Exposed group

Description:

Children age 5-10 years old who had a total serum bilirubin \> 450 umol/L in the neonatal period

Treatment:

Procedure: Movement assessment battery for children - 2

Non-exposed group

Description:

Matched 1:1 to the exposed group on gender, age, gestational age and municipality of residence

Treatment:

Procedure: Movement assessment battery for children - 2