Follow up of Patients With Aortic Aneurysm by Dosage of Circulant Endothelial Progenitor Cells (ANOPEC 3)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Thoracic or Abdominal Aortic Aneurysm With no Indication for Surgical Treatment

Treatments: Biological: blood taking

Study type: Interventional

Funder types: Other

Identifiers

NCT02919709

P/2013/186

Details and patient eligibility

About

The study aims to investigate the existence of a reliable correlation between the progression of aortic diameters and blood levels of circulant endothelial progenitor cells CD34+ in patients with not surgical aortic aneurysms.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients aged 18 or more.
2. Patients diagnosed with a thoracic or abdominal aortic aneurysm with no indication for surgical treatment (diameters > 30 mm but < 50 mm).
3. Patients accepting to sign a specific informed consent.

Exclusion criteria

1. Unstable coronary artery disease.
2. Congenital heart disease.
3. Any evolving infectious syndrome or viral infection (HIV, HBV or HCV).
4. Any chronic inflammatory or autoimmune disease.
5. Prior administration of G-CSF; EPO; GM-CSF.
6. Liver failure.
7. Prior oncologic disease or ongoing cancer with a life expectancy < 1 year.
8. Dementia.
9. Pregnancy.
10. Patients aged < 18.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

thoracic or abdominal aortic aneurysm

Experimental group

Treatment:

Biological: blood taking