Food Anthocyanins and Flavanols as a Strategy for a Healthy Ageing: Cardiovascular Health and Cognitive Performance (POLYAGE)

Higher Council for Scientific Research (CSIC)

Status: Completed

Conditions: Healthy Aging

Treatments: Other: Cocoa flavanols and berries anthocyanins

Study type: Interventional

Funder types: Other

Identifiers

NCT04348162

AGL2016-76832-R

Details and patient eligibility

About

The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.

Full description

The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.

Healthy volunteers are recruited to participate in a parallel study (n 30 per group) for 10 to 12 weeks. Markers of cardiovascular health (FMD, markers of inflammation and fatty acid metabolism) and cognition (neuropsychological tests and plasma neurotrophins) are being measured before and after intervention.

Enrollment: 90 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 50-85
• BMI 20-32 Kg/m2

Exclusion criteria

• Mini-mental state examination (MMSE) < 28
• Systolic blood pressure (SBP) >139 mmHg
• Diastolic blood pressure (DBP) > 89 mmHg
• Total cholesterol > 6.5 mmol/L

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 4 patient groups

Cocoa Flavanols

Active Comparator group

Description:

Cocoa is taken every day for 10-12 weeks.

Treatment:

Other: Cocoa flavanols and berries anthocyanins

Berries anthocyanins

Active Comparator group

Description:

Red-berries are taken every day for 10-12 weeks.

Treatment:

Other: Cocoa flavanols and berries anthocyanins

Cocoa flavanols plus berries anthocyanins

Active Comparator group

Description:

Cooa and red-berries are taken every day for 10-12 weeks.

Treatment:

Other: Cocoa flavanols and berries anthocyanins

Control

No Intervention group

Description:

Normal diet for 10-12 weeks