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Food Intake and the Adolescent Brain (ADOB)

University of Colorado Denver (CU Denver) logo

University of Colorado Denver (CU Denver)

Status

Completed

Conditions

Feeding Behavior
Adolescent
Brain

Treatments

Dietary Supplement: Energy Stimulus

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT04208256
K01DK120562 (U.S. NIH Grant/Contract)
19-1171

Details and patient eligibility

About

The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.

Enrollment

63 patients

Sex

All

Ages

13 to 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • male or female
  • 13-18 years-old
  • resident of Colorado

Exclusion criteria

  • weigh less than 88 pounds or have a BMI% rank of <10% for age and sex;
  • have a physician's diagnosis of metabolic syndrome or diabetes (Type 1 or 2);
  • have a physician's diagnosis of anorexia nervosa or bulimia nervosa;
  • currently taking anti-psychotic medications (not including anti-depressant or anti- anxiety medications);
  • have a non-MRI safe device (e.g. pacemaker or defibrillator) or metal in the body (e.g. metal pins, shrapnel);
  • experience symptoms of claustrophobia when in small or closed-off places;
  • are pregnant or plan to become pregnant

Trial design

63 participants in 2 patient groups

Energy Neutral
Description:
Bottled water (300 ml) with added fruit punch-flavored non-nutritive sweetener (aspartame) will be used as the energy neutral stimulus.
Treatment:
Dietary Supplement: Energy Stimulus
Energy Surplus
Description:
300ml fruit punch-flavored Glucola (75-gram\[g\], Azer Scientific) will be used as the energy surplus stimulus.
Treatment:
Dietary Supplement: Energy Stimulus

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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