Food Rheology and Feeding in Lean and Obese Humans

Purdue University

Status: Completed

Conditions: Overweight; Diabetes; Obesity

Treatments: Other: food in solid form; Other: food in fluid form

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00260130

DK63185 (completed)

Study 2: 508002908

Study 3: 505002589

R01DK063185 (U.S. NIH Grant/Contract)

Study 1: 503001275

Details and patient eligibility

About

The 2010 National Health Objectives call for a reduction in the prevalence of obesity. The marked recent increase in overweight and obesity prevalence implicates behavioral factors in the etiology of the epidemic. The present proposal hypothesizes the trend is attributal, in part, to increasing consumption of energy-yeilding beverages since they are a significant and increasing source of dietarty energy and they elicit weaker appetitive and dietary responses than solid foods.

Full description

Three human studies are propsed to more fully characterized attributes of liquids and solids that may account for the differential appetitive responses they elicit, potential contributory mechanisms as well as the dietary implications of their consumption. Study 1 will contrast the acute effects of fluid and solid foods varying in macronutrient content on satiation, satiety and feeding. Study 2 will determine if the pattern of fluid and solid ingestion influences satiety and feeding by monitoring appetitive and dietary responses to energy and macronutrient matched fluid and solid loads ingested as meal components or between meal snacks. To better assess the clinical implications ofdiets incorpprating liquid or solid supplements. Study 3 will entail chronic ingestion of matched energy yeilding fluid or solid loads with concurrent measurement of appetite, dietary intake, energy expenditureand body weight/composition.

Enrollment: 34 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18-23 or 27-35
• weight stable
• constant habitual activity pattern
• low fruit/vegetable consumer
• non-restrained eater

Exclusion criteria

• diabetic
• taking medication known to influence appetite

Trial design

34 participants in 2 patient groups

1

Active Comparator group

Description:

Consuming fruit and vegetable juice

Treatment:

Other: food in fluid form

2

Active Comparator group

Description:

Consuming whole fruits and vegetables

Treatment:

Other: food in solid form