Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children

Zhejiang University

Status: Completed

Conditions: Atopic Dermatitis; Chronic Urticaria; Conjunctivitis, Allergic; Asthma, Allergic; Rhinitis, Allergic

Study type: Observational

Funder types: Other

Identifiers

NCT06063044

No. 2022-0380

Details and patient eligibility

About

Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of immunoglobulin G4(IgG4) in allergic diseases is still worth exploring.we have collected the data of allergic patients aged 0-14 years for retrospective cross-sectional analysis to evaluate the positive rates of total IgE, HDM IgE, FS-IgE and FS-IgG4. Meanwhile, investigators screened out patients who were treated with FS-IgG4-guided elimination diets with/without probiotics for more than 3 months to clarify the role of FS-IgG4 in childhood allergic diseases by assessing the improvement of clinical symptoms before and after treatment.

Full description

Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. And management of allergic diseases beyond medication, such as food management is also very important. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of immunoglobulin G4(IgG4) in allergic diseases is still worth exploring.In present study, investigators have collected the data of allergic patients aged 0-14 years for retrospective cross-sectional analysis to evaluate the positive rates of total IgE, house dust mite (HDM) IgE, FS-IgE and FS-IgG4. Meanwhile, investigators screened out patients who were treated with FS-IgG4-guided diet elimination with/without probiotics for more than 3 months to clarify the role of FS-IgG4 in childhood allergic diseases by assessing the improvement of clinical symptoms before and after treatment. This retrospective study was conducted to clarify the clinical relevance of food-specific IgG4 in allergic diseases and the effect of dietary avoidance on clinical symptoms, thus making a breakthrough in the diagnosis and treatment of childhood allergies.

Enrollment: 407 patients

Sex: All

Ages: 8 months to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of allergic rhinitis.

• Clinical diagnosis of asthma.
• Clinical diagnosis of conjunctivitis.
• Clinical diagnosis of urticaria.
• Clinical diagnosis of atopic dermatitis.
• Total IgE,FS-IgE, HDM-IgE and FS-IgG4 must be tested.

Exclusion criteria

· Autoimmune diseases.

Trial design

407 participants in 3 patient groups

Respiratory system group

Description:

the patients who diagnosed as rhinitis, asthma and conjunctivitis were assigned to the respiratory system group

Skin system group

Description:

the patients who diagnosed as urticaria and atopic dermatitis were assigned to the skin system group

Multiple systems group

Description:

the patients who diagnosed with a combination of symptoms from different systems were assigned to the multiple systems group