Force Control in Chronic Obstructive Pulmonary Disease (NEUROTIGUE F)

Intermunicipal Hospital Center Toulon

Status

Completed

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Treatments

Other: Submaximal isometric contractions of knee extensors

Study type

Observational

Funder types

Other

Identifiers

NCT06871670

2025-CHITS-005

Details and patient eligibility

About

Maximal muscle strength is one of the most commonly assessed neuromuscular parameters in people with COPD due to its accessibility and relevance for prescribing an appropriate workload for resistance training. However, maximal force production is very rarely necessary during daily activities which requires production of submaximal and precisely controlled forces. Despite growing research on motor impairments in COPD, very little attention has been given to the effect of this disease on force control. Therefore, this research aims to better understand the potential deficits in force control caused by COPD, through the use of advanced signal processing methods (i.e., nonlinear approaches). We hypothesized that force control would be reduced in people with COPD compared to healthy individuals, particularly at low force levels.

Full description

This observational study is based on the analyses of data (force signals) recorded during the first visit of NEUROTIGUE study (NCT04028973).

Force signals were recorded during brief submaximal isometric contractions of the knee extensors performed by both COPD patients and healthy individuals. Each participant performed contractions at different intensity of his/her maximal muscle strength : 10, 20, 30, 40, 50 and 60%. Two contractions of approximately 6s duration were performed at each intensity by all participants. For a given intensity (e.g., 10%), both contractions were performed in a row but different intensities were accomplished in a random order.

Force control will be assess using a conjunction of parameters to provide a comprehensive understanding of force variability (e.g., coefficient of variation, non-linear approaches).

Enrollment

36 patients

Sex

All

Ages

40+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

COPD patients :

GOLD II - III or IV
FEV1 <80% of predicted values
Men and women aged 40 years and over
French-speaking participant
BMI <30 kg / m²
Stable condition (i.e. without exacerbation) for more than 15 days
Able to express their consent in writing prior to any participation in the study
Affiliates or beneficiaries of a social security
Minimum score of 26 on the MMSE questionnaire of 3 months or less

Healthy volunteers :

Men and women aged 40 years and over
French-speaking participant
BMI <30 kg / m²
No known chronic respiratory, cardiovascular, metabolic, renal or neuromuscular pathologies
Able to express their consent in writing prior to any participation in the study
Affiliates or beneficiaries of a social security
Minimum score of 26 on the MMSE questionnaire of 3 months or less

For all participants :

-Subject who has not objected to the reuse of data collected

Exclusion criteria

COPD patients :

Alcoholism, i.e. > 21 glasses a week for men and >14 glasses a week for women
Psychiatric pathologies or antecedent of behavioral disorders
Patients treated with oral or systemic corticosteroids (> 0.5 mg / kg / day for > 7 days)
Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
Severe vision or hearing problems not corrected
Patient oxygen dependent
Patients in exclusion period from another research protocol
Pregnant women (known pregnancy) or lactating women
Patient deprived of liberty by a judicial or administrative decision
Patient subject to a legal protection measure or unable to express their consent
Patient who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
Patient unable to follow study procedures and to respect visits throughout the study period
Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study

Healthy volunteers:

Alcoholism, i.e. > 21 glasses a week for men and >14 glasses a week for women
Psychiatric pathologies or antecedent of behavioral disorders
Patients treated with oral or systemic corticosteroids (> 0.5 mg / kg / day for > 7 days)
Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
Severe vision or hearing problems not corrected
Subjects in exclusion period from another research protocol
Pregnant women (known pregnancy) or lactating women
Regular physical activity with a frequency greater than 3 sessions per week
Participant deprived of liberty by a judicial or administrative decision
Participant subject to a legal protection measure or unable to express their consent
Participant who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
Participant unable to follow study procedures and to respect visits throughout the study period
Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study