Formulations of Liposomal Local Anesthetics

University of Campinas, Brazil

Status and phase: Completed; Phase 1

Conditions: Underdosing of Local Anesthetics, Initial Encounter

Treatments: Drug: Ropivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01307969

164/2006

Details and patient eligibility

About

This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated ropivacaine formulation for dental anesthesia.

Full description

This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated 0, 5% ropivacaine for dental anesthesia after maxillary infiltration.

Enrollment: 40 patients

Sex: All

Ages: 18 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy

Exclusion criteria

• Volunteers were free from cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and haematological diseases, psychiatric disorders and allergy to local anesthetics

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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40 participants in 1 patient group

Anesthetic efficacy

Experimental group

Description:

Local anesthetics were injected at the apex of the maxillary right canine.

Treatment:

Drug: Ropivacaine