Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus (FFTKC)

Democritus University of Thrace

Status

Completed

Conditions

Keratoconus

Study type

Observational

Funder types

Other

Identifiers

NCT02617368

304/23/11/2015

Details and patient eligibility

About

Primary objective of this study was evaluate the diagnostic capacity of fourier analysis of keratometric data in differentiating moderate KC and FFK from healthy corneas.

Study participants were recruited from the Cornea Outpatient service in a consecutive if eligible basis. Two study groups were formed: a)KC group included patients those were diagnosed and classified for moderate keratoconus according to the Amsler-Krumeich classification system, b) FFK group (FFKG) that included patients diagnosed with FFK, and c) Control group (CG) was formed by refractive surgery candidates. Pentacam (Pentacam HR, Oculus Optikgerate GmbH, Heidelberg, Germany)measurements were performed by the same experienced operator in a consistent way.

Enrollment

185 patients

Sex

All

Ages

8+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

diagnosis of keratoconus KC in the fellow eye according to the Amsler-Krumleich criteria (FFKG)
KISA index between 60 and 100% in the FFK eye (FFKG)
lack of any KC-related findings / signs in the slit-lamp biomicroscopy (FFKG)
uneventful ophthalmologic history (CG)
no indications of corneal pathology in slit-lamp biomicroscopy and Placido *disk-based videokeratography (CG)
KISA index value less than 60% (CG)
diagnosed and classified for moderate keratoconus according to the Amsler-Krumeich classification system (KCG)

Exclusion criteria

for all study groups:
- previous incisional eye surgery
- corneal scars and opacities
- history of herpetic keratitis, severe eye dryness
- pregnancy or nursing
- current corneal infection
- glaucoma
- suspicion for glaucoma
- IOP lowering treatment
- underlying autoimmune disease