Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients

Hospital Universitario Dr. Jose E. Gonzalez

Status: Completed

Conditions: Fournier's Gangrene of Penis; Fournier's Gangrene of Scrotum; Fournier Gangrene

Treatments: Procedure: Aggressive debridement

Study type: Observational

Funder types: Other

Identifiers

NCT03443544

UR16-00003

Details and patient eligibility

About

Background:

Fournier's gangrene it's a necrotizing infection of the genital area, with high morbidity and mortality. The site of infection its the origin of the necrotizing fasciitis. There are 4 well known origins of Fournier's gangrene: Testicular, Intestinal, Urinary and cutaneous, and its prognostic value has not been established yet, that's because the lack of case series with adequate number of patients. This is a retrospective study in which we evaluate the prognostic factors of every patient and its mortality compared with its origin area and multiple scores with their survival rates and hospital stay.

Full description

Objective:

To evaluate origins of Fournier's gangrene as a prognostic value in the morbidity and mortality.

Patients and methods:

This is a retrospective study where patients from a single hospital from 2007 to 2016 were included. They were categorized in 4 groups matching the origin of infection. In every group categorizing with the origin of infection and determined severity factors, days of hospital stay, Fournier's gangrene severity index and mortality. A statistic analysis will be done using lineal multivariable analysis.

Enrollment: 121 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Male Patient
• Fournier's Gangrene
• All patients treated with two antibiotics
• All patients undergone with aggressive debridement

Exclusion Criteria

• Female
• Not having Fournier's Gangrene

Trial design

121 participants in 4 patient groups

Intestinal origin

Description:

Either perianal abcess or rectal carcinoma

Treatment:

Procedure: Aggressive debridement

Testicular Origin

Description:

Complicated epididymitis with fascitis,

Treatment:

Procedure: Aggressive debridement

Urinary Origin

Description:

From urinary tract infection or fistulae from urethral trauma

Treatment:

Procedure: Aggressive debridement

Cutaneous Origin

Description:

mostly folliculitis, and skin infections

Treatment:

Procedure: Aggressive debridement