FoxBioNet Pilot Project: SAVE (Synuclein Assay Validation Effort) (SAVE001)

Michael J. Fox Foundation for Parkinson's Research

Status

Completed

Conditions

Parkinson Disease

Treatments

Procedure: Procedure/Surgery: Biofluid samplings

Study type

Observational

Funder types

Other

Identifiers

NCT03170063

SAVE001

Details and patient eligibility

About

The overall objective of this study is to compare the performance of available oligomeric and phosphorylated a-synuclein assay in cerebrospinal fluid and blood.

Full description

Specific aims to accomplish this objective are:

Assess the reliability of oligomeric and phosphorylated a-synuclein concentration between two different oligomeric and three phosphorylated asynuclein assays.
Assess the reliability of the oligomeric and phosphorylated a-synuclein concentrations between laboratories
Assess the correlation of oligomeric and phosphorylated a-synuclein concentrations between cerebrospinal fluid and blood.

1.2. Secondary Objectives

To assess the ability of the network of pilot sites to efficiently conduct a study involving biosample collection for PD research. Efficiency will be assessed using measures of the time taken to meet specific milestones within the study.
To assess the ability of the network to collect high quality biospecimens adhering to agreed-upon protocols.
To gauge the willingness of participants to participate in subsequent Fox BioNet studies

Enrollment

54 patients

Sex

All

Ages

30+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Parkinson's Disease Subjects

Patients must meet the MDS criteria for Parkinson's disease.
Disease duration: any
Male or female age 30 years or older at time of PD diagnosis.

Control Subjects

Male or female age 30 years or older at Screening.

Exclusion criteria

Parkinson's Disease Subjects

Inability to provide informed consent
Current treatment with anticoagulants (e.g., coumadin, heparin) that might preclude safe completion of the lumbar puncture.
Condition that precludes the safe performance of routine lumbar puncture, such as prohibitive lumbar spinal disease, bleeding diathesis, or clinically significant coagulopathy or thrombocytopenia.
Participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans.

Control Subjects

Inability to provide informed consent
Current treatment with anticoagulants (e.g. coumadin, heparin) that might preclude safe completion of the lumbar puncture.
Condition that precludes the safe performance of routine lumbar puncture, such as prohibitive lumbar spinal disease, bleeding diathesis, or clinically significant coagulopathy or thrombocytopenia.
Participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans.
The presence of rest tremor, bradykinesia or rigidity.
The presence of any other neurological sign that in the opinion of the site investigator raises suspicion for an atypical parkinsonian syndrome (e.g. supranuclear gaze palsy)