Fractalkine-CX3CR1 Axis in Periodontal Therapy

Giresun University

Status: Completed

Conditions: Periodontitis; Inflammation Biomarkers; Gingivitis

Treatments: Other: Non-surgical periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT07307144

OMU KAEK 2022/85

SAĞ-BAP-A-240222-47 (Other Grant/Funding Number)

Details and patient eligibility

About

This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.

Full description

Thirty stage 3 periodontitis, thirty gingivitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; gingivitis and periodontitis patients underwent non-surgical periodontal treatment, and GCF samples were collected at baseline and at 1 and 3 months after treatment. CX3CL1 and CX3CR1 were determined by ELISA.

Enrollment: 90 patients

Sex: All

Ages: 25 to 47 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 25-50 years of age
2. having at least 20 natural teeth, excluding third molars
3. having no systemic disease
4. non-smokers
5. criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction
6. criteria for stage 3 periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Exclusion criteria

1. having any systemic diseases,
2. smoking
3. current pregnancy or lactation
4. a history of periodontal treatment in the past 6 months
5. using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

stage 3 periodontitis

Active Comparator group

Description:

GCF samples were collected at baseline and at 1 and 3 months after treatment from periodontitis patients.

Treatment:

Other: Non-surgical periodontal treatment

Gingivitis

Active Comparator group

Description:

GCF samples were collected at baseline and at 1 and 3 months after treatment from gingivitis patients.

Treatment:

Other: Non-surgical periodontal treatment

Periodontally healthy controls

No Intervention group

Description:

GCF samples were collected from periodontally healthy controls at baseline for once.