Fraction of Inspired Oxygen and Atelectasis in Children

Seoul National University

Status: Completed

Conditions: Pulmonary Atelectasis

Treatments: Other: Respiratory management; Device: Lung ultrasound

Study type: Interventional

Funder types: Other

Identifiers

NCT02870842

H-1607-150-778

Details and patient eligibility

About

Investigators hypothesized that maintaining low fraction of inspired oxygen would be beneficial to prevent anesthesia-induced atelectasis in mechanically ventilated children undergoing general anesthesia.

Enrollment: 86 patients

Sex: All

Ages: Under 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Expected operation time between 1 to 3 hours under general anesthesia
• Mechanically ventilated after endotracheal intubation

Exclusion criteria

• Cardiac, thoracic, abdominal surgery
• History of surgery on the lungs
• Laparoscopic surgery
• Abnormal preoperative chest radiograph findings including atelectasis, pneumothorax, pleural effusion, and pneumonia
• Considered inappropriate by the investigator

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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86 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

Perform recruitment maneuver with fraction of inspired oxygen (FiO2) of 1.0 after intubation under lung ultrasound guidance and maintain FiO2 of 0.6 during the general anesthesia.

Treatment:

Device: Lung ultrasound

Other: Respiratory management

Low FiO2

Active Comparator group

Description:

Perform recruitment maneuver with low FiO2 of 0.3 after intubation under lung ultrasound guidance and maintain FiO2 of 0.3 during the general anesthesia.

Treatment:

Device: Lung ultrasound

Other: Respiratory management