Frailty Among Renal Transplant Recipients and Relation to Chronic Allograft Dysfunction

Alexandria University

Status: Enrolling

Conditions: Frailty; Renal Transplant

Treatments: Diagnostic Test: assessment of frailty

Study type: Interventional

Funder types: Other

Identifiers

NCT07181096

frailty in renal transplant

Details and patient eligibility

About

The aim of the study is to assess prevalence of frailty among renal transplant recipients in Alexandria University Hospitals and to study the relation between frailty and chronic allograft dysfunction.

Full description

With respect to correlates of frailty, although higher comorbidity burden is also a risk factor for frailty among KT candidates, frailty can also occur in the setting of lower comorbidity burdens. Diabetes and serum albumin concentration are also associated with frailty among prevalent dialysis patients.

In addition, individuals with CKD and ESKD who are frail are also more likely to have cognitive impairment and sarcopenia, or low muscle mass, than their non-frail counterparts

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Renal transplanted patients with GFR more than 30

Exclusion criteria

• Mentally or physically unfit patients.
• Amputation of lower limb.
• Active neoplasia, chronic liver disease, previous immunological disease.
• Psychiatric disorders.
• Pregnancy.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

renal transplant patients

Experimental group

Description:

patients will be subjected to: 1. Assessment of frailty by Clinical Frailty Scale. 2. Assessment of nutritional status using Patient Generated Subjective Global Assessment (PG-SGA). 3. Comorbidity assessment using Charlson comorbidity score. 4. Six minutes walk test. 5. Muscle strength assessment using hand grip strength (HGS) dynamometer.

Treatment:

Diagnostic Test: assessment of frailty