Frailty and Health-related Quality of Life in Older Women With Breast Carcinoma

Ain Shams University

Status: Not yet enrolling

Conditions: Breast Cancer Females; Frailty

Treatments: Other: Clinical Frailty Scale; Other: Comprehensive geriatric assessment; Other: European Organization for Research and Treatment-Quality of life questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT07159321

palliative 2025-6

Details and patient eligibility

About

This study addresses a critical gap in the care of older women with breast cancer, a population often underrepresented in clinical research despite their increased vulnerability to treatment-related complications. By examining the relationship between frailty and health-related quality of life (QOL), the study aims to provide evidence-based insights into how geriatric assessments can guide personalized treatment decisions, ensuring that therapeutic benefits outweigh risks. Given that older adults prioritize QOL over survival gains, understanding the impact of frailty on their well-being can help clinicians optimize care plans, reduce adverse outcomes, and improve overall patient-centered outcomes. The findings may also inform the integration of routine geriatric assessments in oncology practice, ultimately enhancing the management of older cancer patients in resource-limited settings like Egypt.

Enrollment: 100 estimated patients

Sex: Female

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Females aged 60 years and older
• Newly diagnosed with pathologically proven breast invasive ductal or lobular carcinoma

Exclusion criteria

• History of cognitive impairment or psychiatric disorders
• Delirium during assessment using the Confusion Assessment Method (CAM test)
• Initiation of chemotherapy before the baseline assessment
• Severe hearing or visual impairment preventing completion of assessment
• Other malignancies (second primary)
• Other breast malignancies (e.g., sarcoma)
• End-organ failure (e.g., renal failure, liver cell failure)

Trial design

100 participants in 1 patient group

Females aged 60 years and older, who are newly diagnosed with pathologically proven breast inva

Treatment:

Other: European Organization for Research and Treatment-Quality of life questionnaire

Other: Comprehensive geriatric assessment

Other: Clinical Frailty Scale