Frailty and Spinal Anesthesia-Induced Hypotension in Elderly

Selcuk University

Status: Not yet enrolling

Conditions: Spinal Anesthesia; Frailty

Study type: Observational

Funder types: Other

Identifiers

NCT06757439

2024-12-1

Details and patient eligibility

About

60 patients aged 65 and older with ASA I-III physical status undergoing elective surgery under spinal anesthesia will be included in the study.

Patients with cardiac arrhythmia, severe heart failure, cerebrovascular disease, or contraindications to neuraxial anesthesia will be excluded. Frailty assessments will be performed using the Clinical Frailty Scale (CFS) version 2.0 by anesthesiologists in preoperative clinics or wards. Participants will be categorized into frail (CFS Level ≥4, Group I) and non-frail (CFS Level ≤3, Group II) groups.

Prior to spinal anesthesia, 8 mL/kg of crystalloids will be administered. Baseline preoperative mean arterial blood pressure (MABP) and heart rate (HR) will be recorded as the average of three measurements in the supine position.

During the study, MABP and HR will be monitored every 2 minutes for the first 20 minutes post-spinal anesthesia, then every 5 minutes until surgery ends. Hypotension (MABP <80% of baseline) will be treated with 5 mg intravenous ephedrine, while bradycardia (HR <50 beats/min) will be treated with 0.5 mg intravenous atropine.

Enrollment: 60 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 65 and older
• ASA I-III physical status
• Undergoing elective surgery under spinal anesthesia

Exclusion criteria

• Patients with cardiac arrhythmia
• Patients with severe heart failure
• Patients with cerebrovascular disease
• Contraindications to neuraxial anesthesia

Trial design

60 participants in 2 patient groups

Frail

Description:

CFS Level ≥4

Non-frail

Description:

CFS Level ≤3