Frailty in Vascular Patients Undergoing Surgery

Imperial College London

Status: Enrolling

Conditions: Peripheral Artery Disease; Vascular Diseases; Aneurysmal Disease; Carotid Artery Diseases

Treatments: Other: Questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT03668821

18HH4445

Details and patient eligibility

About

An observational cohort study of the frailty of vascular surgery patients undergoing intervention and their outcomes.

Full description

Vascular surgical operations are major procedures with significant associated morbidity and mortality. Frailty is a major factor influencing surgical outcome, but the effect on morbidity/mortality and quality of life is poorly understood in vascular surgery. Activity levels play a significant role in frailty and in pre-intervention preparation. It is anticipated that as frailty levels increase, activity levels decrease. It is hypothesised that vascular surgery patients suffer from a high prevalence of frailty and that increasing frailty will lead to increased morbidity and mortality and decreased quality of life.

This initial study will provide the foundations to identify targets for improvement in degree of frailty, appropriateness for surgery and outcome.

This project aims to:

Assess and quantify the prevalence of frailty as well as recording activity levels in the vascular surgery patient cohort Explore the impact of frailty and pre-op activity on surgical outcomes in the vascular surgical patient cohort to guide surgical treatments as well as future studies aimed at improving frailty and activity and thereby quality of life.

Identification of an appropriate metric of frailty for this population group to include activity, is a secondary aim of this proposal.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All patients attending for aortic aneurysm repair, carotid artery surgery and lower limb revascularisation under the care of the Vascular Surgery team
2. Willing and able to give informed written consent

Exclusion criteria

1. Those unable to give informed written consent
2. Those <18 years of age
3. In the opinion of the investigator unable or unwilling to comply with the requirements of the study

Trial design

300 participants in 3 patient groups

Carotid Artery Disease

Description:

Patients with Carotid Artery Disease. Quality of life and frailty questionnaires

Treatment:

Other: Questionnaire

Aneurysmal Disease

Description:

Patients with Aneurysmal Disease. Quality of life and frailty questionnaires

Treatment:

Other: Questionnaire

Peripheral Artery Disease

Description:

Patients with Peripheral Artery Disease. Quality of life and frailty questionnaires

Treatment:

Other: Questionnaire