Frailty Trajectories and Their Association With Health Outcomes

Nanjing Medical University

Status: Completed

Conditions: Frailty Syndrome

Treatments: Other: observation

Study type: Observational

Funder types: Other

Identifiers

NCT05793229

Nanjing Medical University

Details and patient eligibility

About

Frailty is common in gastric cancer survivors and seriously affects their prognosis. Multiple longitudinal follow-up assessment of frailty could provide a better understanding of the frailty change of individuals. Our aims were to identify the longitudinal trajectories of frailty and estimate their association with health outcomes in elderly gastric cancer survivors.

Full description

Our study suggested the significant heterogeneity in frailty trajectories among elderly gastric cancer survivors, and that different trajectories had different effects on health outcomes. Our results infer the necessity for prevention strategies in elderly gastric cancer survivors to manage heterogeneous frailty trajectories.

Enrollment: 381 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed with gastric cancer by endoscopy or pathology;
• received radical gastrectomy the first time;
• aged ≥60 years;
• been able to communicate simply in writing and verbal;
• completed the data collection of all follow-up points.

Exclusion criteria

• received radiotherapy or chemotherapy before surgery;
• had other sites of malignant tumors;
• complicated with severe heart, liver, lung and renal insufficiency;
• had physical disability.

Trial design

381 participants in 3 patient groups

improving frailty

Description:

Class 1

Treatment:

Other: observation

maintaining frailty

Description:

Class 2

Treatment:

Other: observation

deteriorating frailty

Description:

Class 3

Treatment:

Other: observation